The ancients sometimes said that the worst sin is ingratitude, which is a forgetting of the greatness, beauty, truth, and goodness of the Source that is constantly creating us-- in other terms, a forsaking of Being and of the Good.
If we just worry about the big picture, we are powerless. So my secret is to start right away doing whatever little work I can do. I try to give joy to one person in the morning, and remove the suffering of one person in the afternoon. If you and your friends do not despise the small work, a million people will remove a lot of suffering.