If we just worry about the big picture, we are powerless. So my secret is to start right away doing whatever little work I can do. I try to give joy to one person in the morning, and remove the suffering of one person in the afternoon. If you and your friends do not despise the small work, a million people will remove a lot of suffering.
It does seem a strange thing to count suffering as joy, yet there's a truth here in that suffering helps to build one's character. Some of the most beautiful people I know are those who have passed through the flames and come out strengthened. If it happens to clay, why shouldn't it happen to us.